Persistent Inflammation, Immunosuppression and Catabolism Syndrome
نویسندگان
چکیده
منابع مشابه
Persistent Inflammation, Immunosuppression, and Catabolism: Evolution of Multiple Organ Dysfunction.
BACKGROUND Multiple organ dysfunction (MOD) has plagued intensive care units (ICUs) for more than four decades, and its epidemiology has evolved because more patients are surviving previously lethal insults. Over the years, different predominant phenotypes of MOD have been described, all of which have consumed tremendous healthcare resources and have been associated with prolonged ICU stays and...
متن کاملInnate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy
Citation: Horiguchi H, Loftus TJ, Hawkins RB, Raymond SL, Stortz JA, Hollen MK, Weiss BP, Miller ES, Bihorac A, Larson SD, Mohr AM, Brakenridge SC, Tsujimoto H, Ueno H, Moore FA, Moldawer LL, Efron PA and The Sepsis and Critical Illness Research Center Investigators (2018) Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy...
متن کاملPersistent inflammation and immunosuppression: a common syndrome and new horizon for surgical intensive care.
Surgical intensive care unit (ICU) stay of longer than 10 days is often described by the experienced intensivist as a "complicated clinical course" and is frequently attributed to persistent immune dysfunction. "Systemic inflammatory response syndrome" (SIRS) followed by "compensatory anti-inflammatory response syndrome" (CARS) is a conceptual framework to explain the immunologic trajectory tha...
متن کاملA Murine Model of Persistent Inflammation, Immune Suppression, and Catabolism Syndrome
Critically ill patients that survive sepsis can develop a Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PICS), which often leads to extended recovery periods and multiple complications. Here, we utilized a cecal ligation and puncture (CLP) method in mice with the goal of creating a model that concurrently displays all the characteristics of PICS. We observed that, after e...
متن کاملInflammation and immunosuppression in severe acute pancreatitis.
Acute pancreatitis (AP) is a common disease, which usually exists in its mild form. However, in a fifth of cases, the disease is severe, with local pancreatic complications or systemic organ dysfunction or both. Because the development of organ failure is the major cause of death in AP, early identification of patients likely to develop organ failure is important. AP is initiated by intracellul...
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ژورنال
عنوان ژورنال: Critical Care Clinics
سال: 2017
ISSN: 0749-0704
DOI: 10.1016/j.ccc.2016.12.001